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The Seventh Annual Tom Tom Founders Festival is a week-long celebration of innovators, visionaries, and artists who are shaping small cities. The Festival occurs at dozens of venues throughout downtown Charlottesville. 

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Thursday, April 12 • 11:05am - 11:35am
Use of Deep Learning for Environmental Enteropathy Biopsy Image Analysis Now Open

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A major challenge of interpreting clinical biopsy images to diagnose disease is the often striking overlap in histopathology between distinct but related conditions. There is a major clinical need to develop new methods in data science to allow clinicians to translate heterogeneous biomedical data extracted from patient samples into accurate, quantitative, and precise diagnostics. The development of such processes in high dimensional clinical research data will support the progress of “precision medicine”, with improved diagnostics, treatments, and clinical outcomes for patients. In this presentation we show preliminary results from an image analysis platform for the automated extraction of quantitative morphologic phenotypes from gastrointestinal (GI) biopsy images. This method will capture complex GI disease phenotypes, which cannot be measured directly using molecular approaches. We also aim to develop methods in data science to support the integration of this data with clinical and molecular data, enabling the construction of biologically informative and clinically useful integrative prognostic models in our case, in Environmental Enteropathy. EE is an acquired small intestinal inflammatory condition underlying high rates of linear growth stunting in children <5y of age in low- and middle-income countries. The histologic appearance of duodenal EE biopsies significantly overlaps with celiac enteropathy. To identify novel features that distinguish these two enteropathies from healthy tissue, we characterized intestinal mucosal alterations in Pakistani infants with EE using Convolutional Neural Networks (CNN). 

Speakers
avatar for Sana Syed

Sana Syed

Assistant Professor of Pediatrics, Division of Gastroenterology, Hepatology & Nutrition, University of Virginia
Sana Syed, MD MS is a Pediatric Gastroenterologist with advanced training in Nutrition at the University of Virginia. She is on faculty at the University of Virginia in the Center for Global Health with an adjunct faculty appointment at the Aga Khan University, Department of Pedi... Read More →

Sponsors
avatar for Capital One

Capital One

Capital One is a diversified bank that offers a broad array of financial products and service to consumers, small businesses and commercial clients. 
avatar for S&P Global

S&P Global

S&P Global Inc. (prior to April 2016 McGraw Hill Financial, Inc., and prior to 2013 McGraw Hill Companies) is an American publicly traded corporation headquartered in New York City. Its primary areas of business are financial information and analytics. It is the parent company of S&P Global Ratings, S&P Global Market Intelligence, and... Read More →


Thursday April 12, 2018 11:05am - 11:35am
Violet Crown - Theater 3 200 W Main St, Charlottesville, VA 22902

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